An increasing number of low- and middle-income countries (LMICs) are moving toward providing Universal Health Coverage (UHC) as part of their efforts to achieve the Sustainable Development Goals by 2030 (SDGs). To ensure sustainability of the UHC agenda, there is need for evidence-informed priority setting of key interventions. Health Technology Assessment (HTA), a tool for priority setting, has emerged as a powerful means of ensuring the sustainability of a UHC system. However, with the multitude of challenges facing LMICs, such as weak institutions, limited human resource capacity, and funding challenges, institutionalizing HTA becomes a daunting task.